You should be careful to note that in this context you seem to not be talking about a signal transmission line, which is what Joe answered about. Such a transmission line is specifically not a lumped system.
You seem to be talking about "transmission lines" such as transfer power between generating stations and the customers miles away. That's a totally different issue.
The basic answer to your question is that the voltage is NOT the same at both ends. A power transmission line might be labeled as "400 kV", and that will be roughly true. But, these transmission lines have non-zero resistance (except some very specialized superconducting ones). They will therefore develop some voltage accross them when current flows. At this level of detail, the transmission line is just a resistor and Ohm's law applies.
High voltage is used for such transmission lines because that reduces the current for the same power. That's desirable since the losses are proportional to the square of the current. And there ARE losses due to the resistance of the transmission lines, and they do get warm. It's a issue the power companies are well aware of and carefully trade off with other things, like the cost of thicker cable, other losses that start to increase at very high voltages, etc.