I have over the years worked on transformers over the whole spectrum of applications, so here are my observations, for what they are worth. Low power EI transformers for 115 or 230 volts often have the winding's arranged so that a wide range of output voltages can be made available just by changing the secondary winding turns and wire gauge, which means either a side by side arrangement or primary winding closest to the core. This applies in the case where the secondary has a lower or higher voltage than the primary, assuming the standard mains voltages. I used to wind custom output EI mains transformers for widely varying secondary voltages, where we had a range of core sizes, and the associated bobbins pre wound for a 230v primary input.Transformers for power transmission usually have a different core structure, so that all winding's are on different legs of the core, see 3 phase transformers for example for an extreme example. It makes insulation/isolation and cooling simpler for starters, putting aside issues around issues associated with the advantages and disadvantages of the core geometry.I should mention toroidal and planar transformers, but the names are enough, they have difficulties all of there own.Where low leakage inductance is required, the layers are interleaved, as Elizabeth pointed out. You will often see this in SMPS transformers (fly back is a good example) You can see how these transformers are made by looking at the application notes from the companies that make the controller chip sets, it is quite edifying. With careful design, very high voltages are possible. Special transformer adhesive tape (sort of like sellotape) is available that is very thin, and rated at many KV. It has good thermal properties, allowing the transformer to be dip/vacuum coated and baked after manufacturing.Cheers,Richard