Good, MPLAB has plenty of resources to help you get started. Make sure you also have the MPLAB C compiler downloaded as well:
"MPLAB C Compiler":http://www.microchip.com/stellent/idcplg?IdcService=SS_GET_PAGE&nodeId=1406&dDocName=en010014
Then go to:
Help > Topics
In there towards the bottom you will find a C18 getting started guide, as well as a users guide. Go through these carefully and create the sample programs they have you do and make sure you can compile them.
After you get through these and get a feel for whats going on on your own come back here with specific questions on the microcontroller, including code that you have started for your program so we know you are learning on your own and we will help you.