Do an equivalent circuit, assume the transformers are perfect for simplicities sake.
Voltage Generator on the primary of a voltage step up transformer, secondary connected to an equivalent transmission line resistance. Connect the other end of the transmission line to the primary of a voltage step down transformer, the secondary to the load.
Now look at what is happening, all the power is transformed to the load, apart from the power loss in the transmission line. If the turns ratio on the input transformer is adjusted to give a higher secondary voltage, and on the output transformer to give the same load voltage, for the same load power, the current in the transmission line has dropped(this is the same current in secondary of the source transformer and the primary of the output transformer). Since this is the primary source of loss in the whole system, then the power loss must drop.
Best I can do, does that help at all, put the whole circuit into spice if you must, but sketching the whole thing up and analyzing it on a bit of paper should do it just as well,
Cheers,
Richard