Hi,
First of all, are you the one who designed this circuit? If not, its best to know first the function of the circuit. Have you tried using this circuit? Basically in your circuit, you have your PLL which should be synchronous with the signal generated. Then comes your loop filter. So generally, it might work. but the values, i'm not sure.
The 221MHz spectrum is used for Land mobile - base stations according to federal regulations, I'm not sure if your aware of that.