The author's question is NOT "stupid".
Overall the PC is made to be able to run 24/7 but ....
Response:
-> depends on what equipment [motherboard, power supply, gpu, cpu], what reliability and what load.
If it is going to be an extreme load, then you need to provide good cooling.
In addition, it is also necessary to consider how long [how many years] the system is to operate. After a few years on poor equipment [eg. power supply] capacitors may "evaporate".
There is a very nice video on YouTube showing that, under full stress, our beloved PCs, unfortunately, JUST IRRELATELY SLEEP !!!!
http://www.youtube.com/watch?v=JeFyUiV6gxI&feature=related Quote: pc are designed for continuous operation but can't find any official confirmation
When you watch the above video, you will understand why no one dared to do something like this. All in all, even the best computer can be destroyed (not even by unscrewing the case and "throwing" it, and maybe not even overclocking it) in less than a week.
Of course, the video is only illustrative. When choosing an architecture / manufacturer, do NOT limit yourself to just him.
If it is only to be a "server" that will play something on Ethernet from time to time, then practically every ordinary PeCet will be too good.
In addition, you also need to pay attention to the software. So what if the equipment is great, like the program, will hang every 2 days ...
Only the manufacturer's warranty remains.