Micropython in ESP32 - efficient event waiting in the main program

I want to test Micropython in practice on the ESP32. However, I have not had any contact with this language so far. Let's assume that there is a procedure called when an event occurs, e.g:
.

How in the main program to effectively wait for an event to occur?
Is the simplest solution, i.e. a while loop, a good one ?

If we operate on events then we do not actively wait for them.... the occurrence of an event triggers an interrupt, i.e. interrupts the execution of the main program loop and goes to the interrupt handler routine.

https://docs.micropython.org/en/latest/reference/isr_rules.html
https://randomnerdtutorials.com/micropython-interrupts-esp32-esp8266/

Sometimes it can be difficult to write a program that only operates on events and the code itself becomes unreadable.
Let's assume that I need to implement communication via some interface. Establishing a connection, sending and receiving etc. generate the corresponding events.
So I can handle all the events in this way:
.
The main program could look like this:
.
Of course, what I have called the main program can also be placed in an interrupt. The whole thing will work as an automaton. In real
cases, however, such an automaton can be very complicated. It is much simpler to write a linear program like the one above.
Is it effective to wait in a while loop for successive events? Perhaps some other special mechanism has been created for this.